Title: Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Authors: Schneider, Maude ×
Debbané, Martin
Bassett, Anne S
Chow, Eva W C
Fung, Wai Lun Alan
van den Bree, Marianne B M
Owen, Michael
Murphy, Kieran C
Niarchou, Maria
Kates, Wendy R
Antshel, Kevin M
Fremont, Wanda
McDonald-McGinn, Donna M
Gur, Raquel E
Zackai, Elaine H
Vorstman, Jacob
Duijff, Sasja N
Klaassen, Petra W J
Swillen, Ann
Gothelf, Doron
Green, Tamar
Weizman, Abraham
Van Amelsvoort, Therese
Evers, Laurens
Boot, Erik
Shashi, Vandana
Hooper, Stephen R
Bearden, Carrie E
Jalbrzikowski, Maria
Armando, Marco
Vicari, Stefano
Murphy, Declan G
Ousley, Opal
Campbell, Linda E
Simon, Tony J
Eliez, Stephan
for the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome #
Issue Date: Jun-2014
Publisher: American Psychiatric Association
Series Title: American Journal of Psychiatry vol:171 issue:6 pages:627-39
Article number: 10.1176/appi.ajp.2013.13070864
Abstract: OBJECTIVE Chromosome 22q11.2 deletion syndrome is a neurogenetic disorder associated with high rates of schizophrenia and other psychiatric conditions. The authors report what is to their knowledge the first large-scale collaborative study of rates and sex distributions of psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome. The associations among psychopathology, intellect, and functioning were examined in a subgroup of participants. METHOD The 1,402 participants with 22q11.2 deletion syndrome, ages 6-68 years, were assessed for psychiatric disorders with validated diagnostic instruments. Data on intelligence and adaptive functioning were available for 183 participants ages 6 to 24 years. RESULTS Attention deficit hyperactivity disorder (ADHD) was the most frequent disorder in children (37.10%) and was overrepresented in males. Anxiety disorders were more prevalent than mood disorders at all ages, but especially in children and adolescents. Anxiety and unipolar mood disorders were overrepresented in females. Psychotic disorders were present in 41% of adults over age 25. Males did not predominate in psychotic or autism spectrum disorders. Hierarchical regressions in the subgroup revealed that daily living skills were predicted by the presence of anxiety disorders. Psychopathology was not associated with communication or socialization skills. CONCLUSIONS To the authors' knowledge, this is the largest study of psychiatric morbidity in 22q11.2 deletion syndrome. It validates previous findings that this condition is one of the strongest risk factors for psychosis. Anxiety and developmental disorders were also prevalent. These results highlight the need to monitor and reduce the long-term burden of psychopathology in 22q11.2 deletion syndrome.
ISSN: 0002-953X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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