Title: Aging effects on the resting state motor network and interlimb coordination
Authors: Solesio-Jofre, Elena
Serbruyns, Leen
Woolley, Daniel
Mantini, Dante
Beets, Iseult
Swinnen, Stephan # ×
Issue Date: Aug-2014
Publisher: Wiley-Liss
Series Title: Human Brain Mapping vol:35 issue:8 pages:3945-61
Article number: 10.1002/hbm.22450
Abstract: Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics of the resting brain within a task-specific motor network in a sample of 128 healthy participants, aged 18-80 years. We found that age-related increases in functional connectivity between interhemispheric dorsal and ventral premotor areas were associated with poorer performance on a novel bimanual visuomotor task. Additionally, a control analysis performed on the default mode network confirmed that our age-related increases in functional connectivity were specific to the motor system. Our findings suggest that increases in functional connectivity within the resting state motor network with aging reflect a loss of functional specialization that may not only occur in the active brain but also in the resting brain. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
ISSN: 1065-9471
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Movement Control & Neuroplasticity Research Group
× corresponding author
# (joint) last author

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