Balanced Duo of Anti-Inflammatory SFRP5 and Pro-Inflammatory WNT5A in Children
Prats-Puig, Anna × Soriano-Rodríguez, Pilar Carreras-Badosa, Gemma Riera-Pérez, Elena Ros-Miquel, Monserrat Gomila-Borja, Antoni de Zegher, Francis Ibáñez, Lourdes Bassols, Judit López-Bermejo, Abel #
Lippincott Williams & Wilkins
Pediatric Research vol:75 issue:6 pages:793-797
Background:Secreted frizzled-related protein 5 (SFRP5) is an adipokine protecting against obesity-related insulin resistance and diabetes. SFRP5 binds to wingless type MMTV integration site family member 5A (WNT5A) to improve insulin sensitivity. We performed a first study of SFRP5 and WNT5A in children.Methods:Prepubertal children (n=342) were assessed for circulating SFRP5 (all subjects) and circulating WNT5A (210 subjects), and associations were sought with metabolic markers. In conditioned media of adipose tissue explants from 12 additional children, SFRP5 and WNT5A were studied further.Results:The concentrations of SFRP5 and WNT5A correlated positively in serum and in conditioned media (all p<0.001). Lower circulating SFRP5 (lowest quartile) was associated with higher BMI (15% increase, p<0.0001) and lower high molecular weight (HMW) adiponectin (26% decrease, p=0.002). Circulating WNT5A related closely with insulin resistance assessed by the homeostasis model assessment for insulin resistance (HOMA-IR) and hepatic markers (alanine transaminase (ALT) and gamma glutamyl transpeptidase (GGT)), particularly in children with lower circulating SFRP5 (all p<0.004).Conclusion:SFRP5 and WNT5A are a balanced duo that may regulate metabolic homeostasis in prepubertal children.Pediatric Research (2014); doi:10.1038/pr.2014.29.