Title: Dental Implant Macro-Design Features Can Impact the Dynamics of Osseointegration
Authors: Vivan Cardoso, Marcio ×
Vandamme, Katleen
Chaudhari, Amol
De Rycker, Judith
Van Meerbeek, Bart
Naert, Ignace
Duyck, Joke #
Issue Date: 17-Nov-2013
Series Title: Clinical Implant Dentistry and Related Research vol:17 issue:4 pages:639-645
Abstract: PURPOSE:

The purpose of this study was to compare the clinical performance of two dental implant types possessing a different macro-design in the in vivo pig model.


Titanium AadvaTM implants (GC, Tokyo, Japan) were compared with OsseoSpeedTM implants (Astra, Mölndal, Sweden), with the Aadva implant displaying significant larger inter-thread dimensions than the OsseoSpeed implant. Implants were installed in the parietal bone of 12 domestic pigs and left for healing for either 1 or 3 months. Implant osseointegration was evaluated by quantitative histology (bone volume relative to the tissue volume [BV/TV]; bone-to-implant contact [BIC]) for distinct implant regions (collar, body, total implant length) with specific implant thread features. The Wilcoxon-Mann-Whitney nonparametric test with α = 0.05 was performed.


An inferior amount of bone enveloping the Aadva implant compared with the OsseoSpeed implant was observed, in particular at the implant body part with its considerable inter-thread gaps (p < .05). Concomitantly, the Aadva macro-design negatively affected the amount of bone in direct contact with the implant for this specific implant part (p < .05), and resulted in an overall impaired implant osseointegration at the initial healing stage (total implant length; 1-month healing; p < .05).


Although the Aadva implant displayed a clinically acceptable level of osseointegration, the findings demonstrate that implant macro-design features can impact the dynamics of implant osseointegration. Consideration of specific implant macro-design features should be made relative to the biological and mechanical microenvironment.
ISSN: 1523-0899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomaterials - BIOMAT
× corresponding author
# (joint) last author

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