Title: Antibiotic targeting of the bacterial secretory pathway
Authors: Smitha Rao, C V ×
De Waelheyns, Evelien
Economou, Anastassios
Anné, Jozef #
Issue Date: Aug-2014
Publisher: Elsevier BV
Series Title: Biochimica et Biophysica Acta vol:1843 pages:1762-1783
Article number: S0167-4889(14)00051-2
Abstract: Finding new, effective antibiotics is a challenging research area driven by novel approaches required to tackle unconventional targets. In this review we focus on the bacterial protein secretion pathway as a target for eliminating or disarming pathogens. We discuss the latest developments in targeting the Sec-pathway for novel antibiotics focusing on two key components: SecA, the ATP-driven motor protein responsible for driving preproteins across the membrane and the Type I signal peptidase that is responsible for the removal of the signal peptide allowing the release of the mature protein from the membrane. We take a bird's-eye view of other potential targets in the Sec-pathway as well as other Sec-dependent or Sec-independent protein secretion pathways as targets for the development of novel antibiotics. This article is part of a Special Issue entitled: Protein Trafficking & Secretion.
ISSN: 0006-3002
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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