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Title: Endothelial calcium dynamics, connexin channels and blood-brain barrier function
Authors: De Bock, Marijke ×
Wang, Nan
Decrock, Elke
Bol, Mélissa
Gadicherla, Ashish K
Culot, Maxime
Cecchelli, Romeo
Bultynck, Geert
Leybaert, Luc #
Issue Date: Sep-2013
Publisher: Pergamon Press
Series Title: Progress in Neurobiology vol:108 pages:1-20
Article number: 10.1016/j.pneurobio.2013.06.001
Abstract: Situated between the circulation and the brain, the blood-brain barrier (BBB) protects the brain from circulating toxins while securing a specialized environment for neuro-glial signaling. BBB capillary endothelial cells exhibit low transcytotic activity and a tight, junctional network that, aided by the cytoskeleton, restricts paracellular permeability. The latter is subject of extensive research as it relates to neuropathology, edema and inflammation. A key determinant in regulating paracellular permeability is the endothelial cytoplasmic Ca(2+) concentration ([Ca(2+)]i) that affects junctional and cytoskeletal proteins. Ca(2+) signals are not one-time events restricted to a single cell but often appear as oscillatory [Ca(2+)]i changes that may propagate between cells as intercellular Ca(2+) waves. The effect of Ca(2+) oscillations/waves on BBB function is largely unknown and we here review current evidence on how [Ca(2+)]i dynamics influence BBB permeability.
URI: 
ISSN: 0301-0082
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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