Title: IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
Authors: Grieco, Fabio A ×
Moore, Fabrice
Vigneron, François
Santin, Izortze
Villate, Olatz
Marselli, Lorella
Rondas, Dieter
Korf, Hannelie
Overbergh, Lut
Dotta, Francesco
Marchetti, Piero
Mathieu, Chantal
Eizirik, Décio L #
Issue Date: Mar-2014
Publisher: Springer-Verlag Heidelberg
Series Title: Diabetologia vol:57 issue:3 pages:502-11
Article number: 10.1007/s00125-013-3135-2
Abstract: Cytotoxic T cells and macrophages contribute to beta cell destruction in type 1 diabetes at least in part through the production of cytokines such as IL-1β, IFN-γ and TNF-α. We have recently shown the IL-17 pathway to be activated in circulating T cells and pancreatic islets of type 1 diabetes patients. Here, we studied whether IL-17A upregulates the production of chemokines by human pancreatic islets, thus contributing to the build-up of insulitis.
ISSN: 0012-186X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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