Title: Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients
Authors: Chen, Zhigang ×
Bouamar, Rachida
Van Schaik, Ron H N
De Fijter, Johan W
Hartmann, Anders
Zeier, Martin
Budde, Klemens
Kuypers, Dirk
Weimar, Willem
Hesselink, Dennis A
Van Gelder, Teun #
Issue Date: Jun-2014
Publisher: Wiley-Blackwell Publishing, Inc.
Series Title: Clinical Transplantation vol:28 issue:6 pages:649-55
Article number: 10.1111/ctr.12346
Abstract: Acute rejection (AR) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single-nucleotide-polymorphisms (SNPs) in cytokines and their receptors may relate to AR. We investigated the relation between AR and SNPs in the genes encoding for IL-2(-330G>T), IL-10(-592C>A and -1082G>A), TGF-β1(915G>C), and IL-2RB(rs228942 C>A and rs228953 C>T) in 325 renal transplant patients during the first year after transplantation. The overall incidence of AR was 15.4%. In multivariate analysis, only the use of induction therapy was correlated with AR (odds ratio 1.9; 95%-confidence interval 1.1 - 3.7; p = 0.04). No statistically significant associations between the SNPs studied and AR were observed. SNPs in the investigated cytokines and their receptors were not associated with the risk of AR. Genotyping patients for these SNPs is unlikely to aid the clinician in adjusting the immunosuppressive therapy for individual patients. This article is protected by copyright. All rights reserved.
ISSN: 0902-0063
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
× corresponding author
# (joint) last author

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