Title: Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation
Authors: Kashyap, P
Gomez Pinilla, Pedro J
Pozo, M J
Cima, R R
Dozois, E J
Larson, D W
Ordog, T
Gibbons, S J
Farrugia, G # ×
Issue Date: Aug-2011
Publisher: Blackwell Science
Series Title: Neurogastroenterology and Motility vol:23 issue:8 pages:760-5
Article number: 10.1111/j.1365-2982.2011.01729.x
Abstract: Depletion of interstitial cells of Cajal (ICC) is associated with several gastrointestinal (GI) motility disorders. Changes in ICC networks are usually detected by immunolabeling for the receptor tyrosine kinase Kit. Ano1 (DOG1 or TMEM16A) was recently described as a marker of ICC in GI tract. Our aim was to determine whether Ano1 immunoreactivity can be used as a reliable marker for ICC in tissues from patients with motility disorders.
ISSN: 1350-1925
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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