Title: CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis
Authors: Menezes, Soraya
Decanine, Daniele
Brassat, David
Khouri, Ricardo
Schnitman, Saul V
Kruschewsky, Ramon
López, Giovanni
Alvarez, Carolina
Talledo, Michael
Gotuzzo, Eduardo
Vandamme, Anne-Mieke
Galvão-Castro, Bernardo
Liblau, Roland
Van Weyenbergh, Johan # ×
Issue Date: 2014
Publisher: BioMed Central
Series Title: Journal of Neuroinflammation vol:11 pages:18
Article number: 10.1186/1742-2094-11-18
Abstract: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no disease-modifying therapies with long-term clinical benefits or validated biomarkers for clinical follow-up in HAM/TSP. Although CD80 and CD86 costimulatory molecules play prominent roles in immune regulation and reflect disease status in multiple sclerosis (MS), data in HAM/TSP are lacking.
ISSN: 1742-2094
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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