Title: SOD1 Plasma Level as a Biomarker for Therapeutic Failure in Cutaneous Leishmaniasis
Authors: Khouri, Ricardo
Silva Santos, Gilvaneia
Soares, George
Costa, Jackson M
Barral, Aldina
Barral-Netto, Manoel
Van Weyenbergh, Johan # ×
Issue Date: Jul-2014
Publisher: Published by the University of Chicago Press for the Infectious Diseases Society of America
Series Title: The Journal of Infectious Diseases vol:210 issue:2 pages:306-10
Abstract: Here we show that increased plasma SOD1 level significantly predicts therapeutic failure to pentavalent antimony in cutaneous leishmaniasis caused by Leishmania braziliensis. In Leishmania amazonensis-infected patients, host SOD1 levels discriminate between localized and drug-resistant diffuse cutaneous leishmaniasis. Using in situ transcriptomics (nCounter), we demonstrate a significant positive correlation between host SOD1 and IFN-alpha/beta mRNAs, as well as interkingdom correlation between host SOD1 and parasite SOD2/4 mRNAs. In human macrophages, SOD1 in vitro treatment increases parasite burden and induces diffuse cutaneous leishmaniasis-like morphology. Thus, SOD1 is a clinically relevant biomarker and a therapeutic target in both localized and diffuse cutaneous leishmaniasis.
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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