SOD1 Plasma Level as a Biomarker for Therapeutic Failure in Cutaneous Leishmaniasis
Khouri, Ricardo Silva Santos, Gilvaneia Soares, George Costa, Jackson M Barral, Aldina Barral-Netto, Manoel Van Weyenbergh, Johan # ×
Published by the University of Chicago Press for the Infectious Diseases Society of America
The Journal of Infectious Diseases vol:210 issue:2 pages:306-10
Here we show that increased plasma SOD1 level significantly predicts therapeutic failure to pentavalent antimony in cutaneous leishmaniasis caused by Leishmania braziliensis. In Leishmania amazonensis-infected patients, host SOD1 levels discriminate between localized and drug-resistant diffuse cutaneous leishmaniasis. Using in situ transcriptomics (nCounter), we demonstrate a significant positive correlation between host SOD1 and IFN-alpha/beta mRNAs, as well as interkingdom correlation between host SOD1 and parasite SOD2/4 mRNAs. In human macrophages, SOD1 in vitro treatment increases parasite burden and induces diffuse cutaneous leishmaniasis-like morphology. Thus, SOD1 is a clinically relevant biomarker and a therapeutic target in both localized and diffuse cutaneous leishmaniasis.