Title: Addicted to secrete - novel concepts and targets in cancer therapy
Authors: Dejeans, Nicolas
Manié, Serge
Hetz, Claudio
Bard, Frédéric
Hupp, Ted
Agostinis, Patrizia
Samali, Afshin
Chevet, Eric # ×
Issue Date: May-2014
Publisher: Elsevier Science Ltd.
Series Title: Trends in Molecular Medicine vol:20 issue:5 pages:242-50
Article number: S1471-4914(13)00213-X
Abstract: The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the UPR in cancer models. However, the UPR may not be the only druggable target of the SP. Moreover, recent studies have revealed other contributions of the SP to cancer development. This article does not intend to describe the well-established implication of UPR signaling pathways in cancer cell life and cell decision, but rather aims at defining the concept of 'tumor cell secretory addiction', from molecular, cellular, and therapeutic perspectives. Furthermore, the implication of UPR modulations in this context will be discussed.
ISSN: 1471-4914
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science