Title: Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation
Authors: Gomez Pinilla, Pedro J
Farro, Giovanna
Di Giovangiulio, Martina
Stakenborg, Nathalie
Némethova, Andrea
de Vries, Annick
Liston, Adrian
Feyerabend, Thorsten B
Rodewald, Hans-Reimwer
Boeckxstaens, Guy
Matteoli, Gianluca # ×
Issue Date: 2014
Publisher: Public Library of Sciene
Series Title: PLoS One vol:9 issue:1 pages:e85304
Article number: 10.1371/journal.pone.0085304
Abstract: Intestinal manipulation (IM) during abdominal surgery results in intestinal inflammation leading to hypomotility or ileus. Mast cell activation is thought to play a crucial role in the pathophysiology of postoperative ileus (POI). However, this conclusion was mainly drawn using mast cell-deficient mouse models with abnormal Kit signaling. These mice also lack interstitial cells of Cajal (ICC) resulting in aberrant gastrointestinal motility even prior to surgery, compromising their use as model to study POI. To avoid these experimental weaknesses we took advantage of a newly developed knock-in mouse model, Cpa3(Cre/+) , devoid of mast cells but with intact Kit signaling.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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