Title: Neuro-anatomical evidence indicating indirect modulation of macrophages by vagal efferents in the intestine but not in the spleen
Authors: Cailotto, Cathy * ×
Gomez Pinilla, Pedro J *
Costes, Léa M
van der Vliet, Jan
Di Giovangiulio, Martina
Némethova, Andrea
Matteoli, Gianluca
Boeckxstaens, Guy #
Issue Date: 2014
Publisher: Public Library of Sciene
Series Title: PLoS One vol:9 issue:1 pages:e87785
Article number: 10.1371/journal.pone.0087785
Abstract: Electrical stimulation of the vagus nerve suppresses intestinal inflammation and normalizes gut motility in a mouse model of postoperative ileus. The exact anatomical interaction between the vagus nerve and the intestinal immune system remains however a matter of debate. In the present study, we provide additional evidence on the direct and indirect vagal innervation of the spleen and analyzed the anatomical evidence for neuroimmune modulation of macrophages by vagal preganglionic and enteric postganglionic nerve fibers within the intestine.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
* (joint) first author
× corresponding author
# (joint) last author

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