Title: Implementation of genomic arrays in prenatal diagnosis: the Belgian approach to meet the challenges
Authors: Vanakker, Olivier ×
Vilain, Catheline
Janssens, Katrien
Van der Aa, Nathalie
Smits, Guillaume
Bandelier, Claude
Blaumeiser, Bettina
Bulk, Saskia
Caberg, Jean-Hubert
De Leener, Anne
De Raedemaker, Marjan
de Ravel de l'Argentière, Thomy
Desir, Julie
Destree, Anne
Dheedene, Annelies
Gaillez, Stéphane
Grisart, Bernard
Hellin, Ann-Cécile
Janssens, Sandra
Keymolen, Kathelijn
Menten, Björn
Pichon, Bruno
Ravoet, Marie
Revencu, Nicole
Rombout, Sonia
Staessens, Catherine
Van Den Bogaert, Ann
Van Den Bogaert, Kris
Vermeesch, Joris
Kooy, Frank
Snajer, Yves
Devriendt, Koenraad #
Issue Date: Mar-2014
Publisher: Elsevier
Series Title: European Journal of Medical Genetics vol:57 issue:4 pages:151-156
Article number: S1769-7212(14)00027-5
Abstract: After their successful introduction in postnatal testing, genome-wide arrays are now rapidly replacing conventional karyotyping in prenatal diagnostics. While previous studies have demonstrated the advantages of this method, we are confronted with difficulties regarding the technology and the ethical dilemmas inherent to genomic arrays. These include indication for testing, array design, interpretation of variants and how to deal with variants of unknown significance and incidental findings. The experiences with these issues reported in the literature are most often from single centres. Here, we report on a national consensus approach how microarray is implemented in all genetic centres in Belgium. These recommendations are subjected to constant re-evaluation based on our growing experience and can serve as a useful tool for those involved in prenatal diagnosis.
ISSN: 1769-7212
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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