Title: Immunopathological effects of malaria pigment or hemozoin and other crystals
Authors: Tyberghein, Ariane ×
K. Deroost, Katrien
Schwarzer, Evelin
Arese, Paolo
Van den Steen, Philippe #
Issue Date: Jan-2014
Publisher: Published for International Union of Biochemistry by IRL Press
Series Title: BioFactors vol:40 issue:1 pages:59-78
Article number: 10.1002/biof.1119
Abstract: Blood-stage malaria parasites produce insoluble hemozoin (Hz) crystals that are released in the blood circulation upon schizont rupture. In general, endogenous crystal formation or inhalation of crystalline materials is often associated with pathology. As the immune system responds differently to crystalline particles than to soluble molecules, in this review, the properties, immunological recognition, and pathogenic responses of Hz are discussed, and compared with two other major pathogenic crystals, monosodium urate (MSU) and asbestos. Because of the size and shape of MSU crystals and asbestos fibers, phagolysosomal formation is inefficient and often results in leakage of lysosomal content in the cell cytoplasm and/or in the extracellular environment with subsequent cell damage and cell death. Phagolysosomal formation after Hz ingestion is normal, but Hz remains stored inside these cells for months or even longer without any detectable degradation. Nonetheless, the different types of crystals are recognized by similar immune receptors, involving Toll-like receptors, the inflammasome, antibodies, and/or complement factors, and through similar signaling cascades, they activate both proinflammatory and anti-inflammatory immune responses that contribute to inflammation-associated pathology. BioFactors, 40(1):59-78, 2014.
ISSN: 0951-6433
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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