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Title: Regioselective hydrolysis of human serum albumin by Zr(IV)-substituted polyoxotungstates at the interface of positively charged protein surface patches and negatively charged amino acid residues
Authors: Stroobants, Karen ×
Absillis, Gregory
Moelants, Eva
Proost, Paul
Parac-Vogt, Tatjana #
Issue Date: 5-Mar-2014
Publisher: VCH Verlagsgesellschaft
Series Title: Chemistry - a European Journal vol:20 pages:3894-3897
Abstract: Complexes comprising the Lewis acidic ZrIV metal and protein binding polyoxotungstate ligands of Lindqvist-, Keggin- and Wells-Dawson-type were found to region selectively hydrolyze human serum albumin at four distinct positions. Higher reactivities were found for structures with higher polyoxometalate charges and the cleavage positions were found in protein regions of mixed charge. Both findings suggest an electrostatic nature of the observed reactivity.
ISSN: 0947-6539
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Molecular Design and Synthesis
× corresponding author
# (joint) last author

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