Title: Fitness and virulence of a Coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta
Authors: Thibaut, Hendrik Jan ×
van der Schaar, Hilde M
Lanke, Kjerstin H W
Verbeken, Erik
Andrews, Martin
Leyssen, Pieter
Neyts, Johan
van Kuppeveld, Frank J M #
Issue Date: Mar-2014
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Virology vol:88 issue:5 pages:3048-51
Article number: 10.1128/JVI.03177-13
Abstract: Coxsackieviruses require phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) for replication but can bypass this need by an H57Y mutation in protein 3A (3A-H57Y). We show that mutant coxsackievirus is not outcompeted by wild-type virus during 10 passages in vitro. In mice, the mutant virus proved as virulent as wild-type virus, even when mice were treated with a PI4KIIIβ inhibitor. Our data suggest that upon emergence, the 3A-H57Y mutant has the fitness to establish a resistant population with a virulence similar to that of wild-type virus.
ISSN: 0022-538X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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