Title: Approaches for drug delivery with intracortical probes
Authors: Spieth, Sven ×
Schumacher, Axel
Trenkle, Fabian
Brett, Olivia
Seidl, Karsten
Herwik, Stanislav
Kisban, Sebastian
Ruther, Patrick
Aarts, Arno A A
Neves, Hercules P
Rich, P Dylan
Theobald, David E
Holtzman, Tahl
Dalley, Jeffrey W
Verhoef, Bram-Ernst
Janssen, Peter
Zengerle, Roland #
Issue Date: Aug-2014
Publisher: Fachverlag Schiele & Schön
Series Title: Biomedizinische Technik vol:59 issue:4 pages:291-303
Article number: 10.1515/bmt-2012-0096
Abstract: Abstract Intracortical microprobes allow the precise monitoring of electrical and chemical signaling and are widely used in neuroscience. Microelectromechanical system (MEMS) technologies have greatly enhanced the integration of multifunctional probes by facilitating the combination of multiple recording electrodes and drug delivery channels in a single probe. Depending on the neuroscientific application, various assembly strategies are required in addition to the microprobe fabrication itself. This paper summarizes recent advances in the fabrication and assembly of micromachined silicon probes for drug delivery achieved within the EU-funded research project NeuroProbes. The described fabrication process combines a two-wafer silicon bonding process with deep reactive ion etching, wafer grinding, and thin film patterning and offers a maximum in design flexibility. By applying this process, three general comb-like microprobe designs featuring up to four 8-mm-long shafts, cross sections from 150×200 to 250×250 µm², and different electrode and fluidic channel configurations are realized. Furthermore, we discuss the development and application of different probe assemblies for acute, semichronic, and chronic applications, including comb and array assemblies, floating microprobe arrays, as well as the complete drug delivery system NeuroMedicator for small animal research.
ISSN: 0013-5585
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Neurophysiology
Laboratory for Neuro- and Psychofysiology
× corresponding author
# (joint) last author

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