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Title: Can positron emission tomography with [18F]-fluorodeoxyglucose after first-line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity?
Authors: Spaepen, Karoline
Stroobants, S
Dupont, Patrick
Thomas, José
Vandenberghe, Peter
Balzarini, Jan
Peeters, Christiane
Mortelmans, Luc
Verhoef, Gregor #
Issue Date: 2001
Publisher: Blackwell science ltd
Series Title: British Journal of Haematology vol:115 issue:2 pages:272-8
Abstract: To assess the ability of restaging positron emission tomography (PET) scanning to predict clinical outcome after first-line treatment in patients with Hodgkin's disease, we included 60 patients with histologically proven HD, who underwent whole-body [(18)F]-fluorodeoxygenase ([(18)F]-FDG)-PET studies after first-line treatment and with a follow-up of at least 1 year. Persistence or absence of residual disease on PET was related to progression-free survival (PFS) using Kaplan-Meier survival analysis. After treatment, 55 patients showed a normal [(18)F]-FDG-PET scan; 50 of 55 remained in complete remission (CR), with a median follow-up of 955 d. Only five patients relapsed (median PFS, 296 d). During follow-up in all five patients, [(18)F]-FDG-PET was the first tool that became positive for relapse. Persistent abnormal [(18)F]-FDG uptake was seen in only five patients; all of them relapsed (median PFS, 296 d). In four of five patients, only PET predicted persistent disease. All relapses were proven histologically. Two-year actuarial PFS rate for negative patients was 91% compared with 0% for positive patients. We concluded that [(18)F]-FDG-PET has an important prognostic role in the post-treatment evaluation of HD patients.
URI: 
ISSN: 0007-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Department of Oncology - miscellaneous
Translational Cell & Tissue Research
Hematology Section (-)
Laboratory of Virology and Chemotherapy (Rega Institute)
Solid State Physics and Magnetism Section
Clinical Residents Medicine
Nuclear Medicine & Molecular Imaging
Research Group Experimental Neurology
Laboratory for Cognitive Neurology
Department of Human Genetics - miscellaneous
# (joint) last author

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