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Title: Placental DNA hypomethylation in association with particulate air pollution in early life
Authors: Janssen, Bram G
Godderis, Lode
Pieters, Nicky
Poels, Katrien
Kicinski, Michal
Cuypers, Ann
Fierens, Frans
Penders, Joris
Plusquin, Michelle
Gyselaers, Wilfried
Nawrot, Tim # ×
Issue Date: Jun-2013
Publisher: BioMed Central
Series Title: Particle and Fibre Toxicology vol:10 issue:22 pages:1-11
Abstract: BACKGROUND: There is evidence that altered DNA methylation is an important epigenetic mechanism in prenatal programming and that developmental periods are sensitive to environmental stressors. We hypothesized that exposure to fine particles (PM2.5) during pregnancy could influence DNA methylation patterns of the placenta. METHODS: In the ENVIRONAGE birth cohort, levels of 5'-methyl-deoxycytidine (5-mdC) and deoxycytidine (dC) were quantified in placental DNA from 240 newborns. Multiple regression models were used to study placental global DNA methylation and in utero exposure to PM2.5 over various time windows during pregnancy. RESULTS: PM2.5 exposure during pregnancy averaged (25th-75th percentile) 17.4 (15.4-19.3) mug/m3. Placental global DNA methylation was inversely associated with PM2.5 exposures during whole pregnancy and relatively decreased by 2.19% (95% confidence interval (CI): -3.65, -0.73%, p = 0.004) for each 5 mug/m3 increase in exposure to PM2.5. In a multi-lag model in which all three trimester exposures were fitted as independent variables in the same regression model, only exposure to PM2.5 during trimester 1 was significantly associated with lower global DNA methylation (-2.13% per 5 mug/m3 increase, 95% CI: -3.71, -0.54%, p = 0.009). When we analyzed shorter time windows of exposure within trimester 1, we observed a lower placental DNA methylation at birth during all implantation stages but exposure during the implantation range (6-21d) was strongest associated (-1.08% per 5 mug/m3 increase, 95% CI: -1.80, -0.36%, p = 0.004). CONCLUSIONS: We observed a lower degree of placental global DNA methylation in association with exposure to particulate air pollution in early pregnancy, including the critical stages of implantation. Future studies should elucidate genome-wide and gene-specific methylation patterns in placental tissue that could link particulate exposure during in utero life and early epigenetic modulations.
URI: 
ISSN: 1743-8977
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Environment and Health - miscellaneous
Interdepartmental Platform Hospital Care
× corresponding author
# (joint) last author

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