Title: Infliximab restores the dysfunctional matrix remodeling protein and growth factor gene expression in patients with inflammatory bowel disease
Authors: de Bruyn, Magali ×
Machiels, Kathleen
Vandooren, Jennifer
Lemmens, Bart
Van Lommel, Leentje
Breynaert, Christine
Van der Goten, Jan
Staelens, Dominiek
Billiet, Thomas
De Hertogh, Gert
Ferrante, Marc
Van Assche, Gert
Vermeire, Severine
Opdenakker, Ghislain
Schuit, Frans
Rutgeerts, Paul
Arijs, Ingrid #
Issue Date: Feb-2014
Publisher: John Wiley & Sons
Series Title: Inflammatory Bowel Diseases vol:20 issue:2 pages:339-52
Article number: 10.1097/01.MIB.0000438430.15553.90
Abstract: Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), a disintegrin and metalloprotease with thrombospondin motifs [ADAM(TS)s] and growth factors are involved in inflammation and tissue damage and repair, all occurring in inflammatory bowel disease (IBD). We studied the impact of anti-inflammatory therapy with infliximab on mucosal expression of these tissue remodeling genes in patients with IBD.
ISSN: 1078-0998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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