Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents
Elayadi, Hanane × Smietana, Michael Vasseur, Jean J Balzarini, Jan Lazrek, Hassan B #
VCH Verlagsgesellschaft mbH
Archiv der Pharmazie vol:347 issue:2 pages:134-41
Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).