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Title: Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents
Authors: Elayadi, Hanane ×
Smietana, Michael
Vasseur, Jean J
Balzarini, Jan
Lazrek, Hassan B #
Issue Date: Feb-2014
Publisher: VCH Verlagsgesellschaft mbH
Series Title: Archiv der Pharmazie vol:347 issue:2 pages:134-41
Article number: 10.1002/ardp.201300260
Abstract: Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).
URI: 
ISSN: 0365-6233
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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