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Title: The serotonin transporter 5-HTTLPR polymorphism in the association between sleep quality and affect
Authors: Hartmann, Jessica A ×
Wichers, Marieke
van Bemmel, Alex L
Derom, Cathérine
Thiery, Evert
Jacobs, Nele
van Os, Jim
Simons, Claudia J P #
Issue Date: Jul-2014
Publisher: Elsevier
Series Title: European Neuropsychopharmacology vol:24 issue:7 pages:1086-90
Article number: S0924-977X(14)00027-3
Abstract: A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (χ(2)=4.16, p=.042 and χ(2)=3.90, p=.048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication.
ISSN: 0924-977X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Clinical Genetics
× corresponding author
# (joint) last author

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