Validation of Endoscopic Activity Scores in Patients With Crohn's Disease Based on a Post Hoc Analysis of Data From SONIC
Ferrante, Marc × Colombel, Jean-Frederic Sandborn, William J Reinisch, Walter Mantzaris, Gerassimos J Kornbluth, Asher Rachmilewitz, Daniel Lichtiger, Simon D'Haens, Geert R Van Der Woude, Christien J Danese, Silvio Diamond, Robert H Oortwijn, Alessandra Faria Tang, Kezhen L Miller, Michael Cornillie, Freddy Rutgeerts, Paul J #
Gastroenterology vol:145 issue:5 pages:978-986.e5
Mucosal healing might alter midterm and long-term outcomes of patients with Crohn's disease (CD) and has become an important end point in clinical trials. However, the minimal degree of mucosal improvement (endoscopic response) required to alter midterm outcomes is not known. We aimed to determine the best definition of endoscopic response by evaluating data on the Simple Endoscopic Score for Crohn's Disease (SES-CD) and the Crohn's Disease Endoscopic Index of Severity (CDEIS) from the Study of Biologic and Immunomodulator Naive Patients in Crohn's Disease (SONIC trial).