Title: White matter microstructural abnormalities in families multiply affected with bipolar I disorder: a diffusion tensor tractography study
Authors: Emsell, Louise ×
Chaddock, C
Forde, N
Van Hecke, W
Barker, G J
Leemans, A
Sunaert, Stefan
Walshe, M
Bramon, E
Cannon, D
Murray, R
McDonald, C #
Issue Date: Jul-2014
Publisher: Cambridge University Press
Series Title: Psychological Medicine vol:44 issue:10 pages:2139-50
Abstract: White matter (WM) abnormalities are proposed as potential endophenotypic markers of bipolar disorder (BD). In a diffusion tensor imaging (DTI) voxel-based analysis (VBA) study of families multiply affected with BD, we previously reported that widespread abnormalities of fractional anisotropy (FA) are associated with both BD and genetic liability for illness. In the present study, we further investigated the endophenotypic potential of WM abnormalities by applying DTI tractography to specifically investigate tracts implicated in the pathophysiology of BD.
ISSN: 0033-2917
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational MRI (+)
× corresponding author
# (joint) last author

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