Title: Epigenetically regulated microRNAs in Alzheimer's disease
Authors: Van den Hove, Daniel L ×
Kompotis, Konstantinos
Lardenoije, Roy
Kenis, Gunter
Mill, Jonathan
Steinbusch, Harry W
Lesch, Klaus-Peter
Fitzsimons, Carlos P
De Strooper, Bart
Rutten, Bart P F #
Issue Date: Apr-2014
Publisher: Elsevier
Series Title: Neurobiology of Aging vol:35 issue:4 pages:731-45
Article number: 10.1016/j.neurobiolaging.2013.10.082
Abstract: Alzheimer's disease (AD) is a complex neurodegenerative disorder involving dysregulation of many biological pathways at multiple levels. Classical epigenetic mechanisms, including DNA methylation and histone modifications, and regulation by microRNAs (miRNAs), are among the major regulatory elements that control these pathways at the molecular level, with epigenetic modifications regulating gene expression transcriptionally and miRNAs suppressing gene expression posttranscriptionally. Epigenetic mechanisms and miRNAs have recently been shown to closely interact with each other, thereby creating reciprocal regulatory circuits, which appear to be disrupted in neuronal and glial cells affected by AD. Here, we review those miRNAs implicated in AD that are regulated by promoter DNA methylation and/or chromatin modifications and, which frequently direct the expression of constituents of the epigenetic machinery, concluding with the delineation of a complex epigenetic-miRNA regulatory network and its alterations in AD.
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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