Title: Reproduction of honeybee workers is regulated by epidermal growth factor receptor signaling
Authors: Formesyn, Ellen M ×
Cardoen, Dries
Ernst, Ulrich R
Danneels, Ellen L
Van Vaerenbergh, Matthias
De Koker, Dieter
Verleyen, Peter
Wenseleers, Tom
Schoofs, Liliane
de Graaf, Dirk C #
Issue Date: 1-Feb-2014
Publisher: Academic Press
Series Title: General and Comparative Endocrinology vol:197 issue:C pages:1-4
Article number: S0016-6480(13)00468-1
Abstract: Eusocial insect societies display a remarkable reproductive division of labor between a single fertile queen and thousands of largely sterile workers. In most species, however, the workers retain the capacity to reproduce, particularly in queenless colonies where typically many workers lay eggs. As yet, the molecular determinants that initiate this shift in worker fertility are still poorly documented. By using RNA interference we here demonstrate that the knockdown of epidermal growth factor receptor, a gene which was previously shown to be involved in queen-worker caste differentiation, also induces reproduction in worker honeybees (Apis mellifera). These data show that worker fertility and queen-worker caste determination partly rely on the same gene regulatory networks, thereby providing a major breakthrough in our understanding of the molecular determinants of the social insects' spectacular reproductive division of labor.
ISSN: 0016-6480
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Ecology, Evolution and Biodiversity Conservation Section
× corresponding author
# (joint) last author

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