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Title: Myocardial cardiotrophin-1 is differentially induced in congenital cardiac defects depending on hypoxemia
Authors: Heying, Ruth ×
Qing, Ma
Schumacher, Katharina
Sokalska-Duhme, Magdalena
Vazquez-Jimenez, Jaime F
Seghaye, Marie-Christine #
Issue Date: Jan-2014
Series Title: Future cardiology vol:10 issue:1 pages:53-62
Article number: 10.2217/fca.13.99
Abstract:  Aim: Cardiotrophin-1 (CT-1) is upregulated by hypoxemia and hemodynamic overload and is characterized by potent hypertrophic and protective properties on cardiac cells. This study aimed to investigate whether CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia. Methods & results: Infants with Tetralogy of Fallot (n = 8) or with large nonrestrictive ventricular septal defect (n = 8) undergoing corrective surgery were investigated. Expression of CT-1 was assessed at mRNA and protein levels in the right atrial and ventricular myocardium. The activation of the STAT-3 and VEGF were measured. Degradation of cardiac troponin-I served as a marker of myocardial damage. CT-1 was detected in all patients with levels negatively correlating to the arterial oxygen saturation. Higher CT-1 expression in Tetralogy of Fallot patients was associated with activation of the JAK/STAT pathway and higher cardiac troponin-I degradation. Conclusion: CT-1 may mediate myocardial hypertrophy and dysfunction in infants with congenital cardiac defects, particularly in those with hypoxemia.
URI: 
ISSN: 1744-8298
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiovascular Developmental Biology
× corresponding author
# (joint) last author

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