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Title: The spread of type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in North America: a phylogeographic approach
Authors: Shi, Mang ×
Lemey, Philippe
Singh Brar, Manreetpal
Suchard, Marc A
Murtaugh, Michael P
Carman, Susy
D'Allaire, Sylvie
Delisle, Benjamin
Lambert, Marie-Ève
Gagnon, Carl A
Ge, Li
Qu, Yihan
Yoo, Dongwan
Holmes, Edward C
Chi-Ching Leung, Frederick #
Issue Date: Dec-2013
Publisher: Academic Press
Series Title: Virology vol:447 issue:1-2 pages:146-154
Article number: 10.1016/j.virol.2013.08.028
Abstract: The emergence and spread of Type 2 Porcine Reproductive and Respiratory Syndrome virus (Type 2 PRRSV) in North America is heavily influenced by the multiple site production system used in the hog industry. However, it is unclear how anthropogenic factors such has this have shaped the current spatial distribution of PRRSV genotypes. We employed Bayesian phylogeographic analyses of 7040 ORF5 sequences to reveal the recent geographical spread of Type 2 PRRSV in North America. The directions and intensities in our inferred virus traffic network closely mirror the hog transportation. Most notably, we reveal multiple viral introductions from Canada into the United States causing a major shift in virus genetic composition in the Midwest USA that went unnoticed by the regular surveillance and field epidemiological studies. Overall, these findings provide important insights into the dynamics of Type 2 PRRSV evolution and spread that will facilitate programs for control and prevention.
ISSN: 0042-6822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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