Title: Recent insights into Candida albicans biofilm resistance mechanisms
Authors: Mathé, Lotte
Van Dijck, Patrick # ×
Issue Date: Nov-2013
Publisher: Springer-Verlag
Series Title: Current Genetics vol:59 issue:4 pages:251-64
Article number: 10.1007/s00294-013-0400-3
Abstract: Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research.
ISSN: 0172-8083
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Microbiology and Biotechnology Section - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Mathé2013biofilm.pdf Published 592KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science