Many researchers have investigated the impact of BRCA gene testing on psychological well-being, but results are equivocal. Heterogeneous findings may point to the role of influencing factors. The current questionnaire study investigates the relationship between genetic testing, psychological well-being, and surveillance behavior. The role of sex, age, SES, carrier status, time since testing, number of children, and coping is examined. The research sample consists of 119 presymptomatic BRCA mutation carriers and non-carriers (Mage=41.71,SD=11.05). Results indicated that genetic testing is related to psychological wellbeing over time. Women report more distress than men, carriers more than non-carriers. Coping at the moment of the genetic testing also influences psychological well-being over time. The more people used an emotion-oriented and problem-oriented coping style at the moment of testing, the lower their psychological wellbeing over time. Results furthermore indicated that surveillance behavior is predicted by sex, carrier status, number of children and problem-oriented coping. Carrier status is the only predictor of prophylactic surgery. Results of this study may contribute to the identification of persons at-risk for lower levels of psychological well-being and surveillance behavior.