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Title: Acyclovir-resistant herpes simplex encephalitis in a patient treated with anti-tumor necrosis factor-α monoclonal antibodies
Authors: Schepers, Kinda ×
Hernandez, Antonio
Andrei, Graciela
Gillemot, Sarah
Fiten, Pierre
Opdenakker, Ghislain
Bier, Jean-Christophe
David, Philippe
Delforge, Marie-Luce
Jacobs, Frédérique
Snoeck, Robert #
Issue Date: Jan-2014
Publisher: Elsevier Science
Series Title: Journal of Clinical Virology vol:59 issue:1 pages:67-70
Article number: 10.1016/j.jcv.2013.10.025
Abstract: Herpes simplex virus is the most common cause of severe sporadic encephalitis. We report a case of herpes simplex type 1-encephalitis in a 50-year-old woman receiving anti-tumor necrosis factor-α monoclonal antibodies adalimumab. Although she was an acyclovir naïve patient, a mixed viral population (wild-type and acyclovir-resistant bearing a thymidine-kinase mutation) was identified in the cerebrospinal fluid. The virus in cerebrospinal fluid evolved and a second thymidine-kinase mutant virus emerged. Combined foscavir and acyclovir treatment resolved the herpes simplex encephalitis. To our knowledge, this is the first report of acyclovir-resistant herpes simplex encephalitis in a patient treated with adalimumab.
URI: 
ISSN: 1386-6532
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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