Title: Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application
Authors: Hendrickx, Maarten
Zatloukalova, M
Hassanzadeh-Ghassabeh, G
Muyldermans, Serge
Gils, Ann
Declerck, Paul # ×
Issue Date: Feb-2014
Publisher: Blackwell Pub.
Series Title: Journal of Thrombosis and Haemostasis vol:12 issue:2 pages:229-236
Abstract: Downregulation of fibrinolysis due to cleavage of C-terminal lysine residues from partially degraded fibrin is mainly exerted by the carboxypeptidase activity of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recently, some intrinsic carboxypeptidase activity (= zymogen activity) was reported for the proenzyme (TAFI), however, there is some discussion about its ability to cleave high molecular weight substrates.
ISSN: 1538-7933
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Therapeutic and Diagnostic Antibodies (+)
× corresponding author
# (joint) last author

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