Title: Detection of DNA Bases and Oligonucleotides in Plasmonic Nanoslits Using Fluidic SERS
Authors: Chen, Chang ×
Ye, Jian
Li, Yi
Lagae, Liesbet
Stakenborg, Tim
Van Dorpe, Pol #
Issue Date: 26-Oct-2012
Publisher: IEEE
Series Title: IEEE Journal of Selected Topics in Quantum Electronics vol:19 issue:3 pages:4600707
IEEE Journal of Selected Topics in Quantum Electronics issue:99
Article number: 10.1109/JSTQE.2012.2226564
Abstract: Raman spectroscopy is a widely used vibrational spectroscopic technique to identify and study chemical compounds. The signal can be strongly enhanced in the presence of metal nanostructures resulting in so-called Surface Enhanced Raman Scattering (SERS). Here we describe the use of SERS for the molecular characterization of DNA molecules inside a nanoslit across a thin, metal coated membrane. Nanoslits with two different dimensions were examined. More specifically, relatively long nanoslits (over 700 nm) with a strong, broad plasmonic coupling mode as well as short nanoslits (100 nm) with a strong Fabry-Pérot resonance for a specific wavelength. Both geometries were fabricated using standard lithographic processes and were coated with gold to enable the excitation of surface plasmons, needed for SERS. Using electrophoresis to actuate the analytes across the nanoslits, we were able to record SERS spectra of a typical DNA base, namely adenine. Similarly, short DNA oligonucleotides were also successfully detected. It is expected that the nanoslit-based fluidic SERS will become a promising real-time detection tool, especially for DNA.
ISSN: 1077-260X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Solid State Physics and Magnetism Section
ESAT - MICAS, Microelectronics and Sensors
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Quantum Chemistry and Physical Chemistry Section
Semiconductor Physics Section
× corresponding author
# (joint) last author

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