Title: Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice
Authors: Dugas, V
Liston, Adrian
Hillhouse, E E
Collin, R
Chabot-Roy, G
Pelletier, A-N
Beauchamp, C
Hardy, K
Lesage, Sylvie # ×
Issue Date: Mar-2014
Publisher: Nature Pub. Group
Series Title: Genes and Immunity vol:15 issue:2 pages:82-7
Article number: 10.1038/gene.2013.65
Abstract: Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) coincide with at least some autoimmune disease susceptibility loci. Herein, we investigate the impact of major insulin-dependent diabetes (Idd) loci in defining the number of DN T cells. We demonstrate that although Idd3, Idd5 and Idd9 loci do not regulate DN T-cell number, NOD mice congenic for diabetes resistance alleles at the Idd13 locus show a partial restoration in DN T-cell number. Moreover, competitive and non-competitive bone marrow chimera experiments reveal that DN T-cell number is defined by a bone marrow-intrinsic, but DN T-cell-extrinsic, factor. This suggests that non-autonomous candidate genes define DN T-cell number in secondary lymphoid organs. Together, our results show that the regulation of DN T-cell number in NOD mice is at least partially conferred by alleles at the Idd13 locus.Genes and Immunity advance online publication, 12 December 2013; doi:10.1038/gene.2013.65.
ISSN: 1466-4879
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research)
× corresponding author
# (joint) last author

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