Title: Incomplete and transitory decrease of glycolysis: A new paradigm for anti-angiogenic therapy?
Authors: Schoors, Sandra *
Cantelmo, Anna Rita *
Georgiadou, Maria
Stapor, Peter
Wang, Xingwu
Quaegebeur, Annelies
Cauwenberghs, Sandra
Wong, Brian W
Bifari, Francesco
Decimo, Ilaria
Schoonjans, Luc
De Bock, Katrien
Dewerchin, Mieke
Carmeliet, Peter # ×
Issue Date: 1-Jan-2014
Publisher: Landes Bioscience
Series Title: Cell Cycle vol:13 issue:1 pages:16-22
Abstract: During vessel sprouting, a migratory endothelial tip cell guides the sprout, while proliferating stalk cells elongate the branch. Tip and stalk cell phenotypes are not genetically predetermined fates, but are dynamically interchangeable to ensure that the fittest endothelial cell (EC) leads the vessel sprout. ECs increase glycolysis when forming new blood vessels. Genetic deficiency of the glycolytic activator PFKFB3 in ECs reduces vascular sprouting by impairing migration of tip cells and proliferation of stalk cells. PFKFB3-driven glycolysis promotes the tip cell phenotype during vessel sprouting, since PFKFB3 overexpression overrules the pro-stalk activity of Notch signaling. Furthermore, PFKFB3-deficient ECs cannot compete with wild-type neighbors to form new blood vessels in chimeric mosaic mice. In addition, pharmacological PFKFB3 blockade reduces pathological angiogenesis with modest systemic effects, likely because it decreases glycolysis only partially and transiently.
ISSN: 1538-4101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Exercise Physiology Research Group
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
* (joint) first author
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Schoors_Incomplete and transitory decrease of glycolysis A new paradigm for anti-angiogenic therapy_Cell Cycle2014.pdf Published 1987KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science