Title: Design, synthesis, antiviral, and cytostatic evaluation of novel isoxazolidine analogues of C-nucleotides
Authors: Grabkowska-Drużyc, Magdalena ×
Balzarini, Jan
Piotrowska, Dorota G #
Issue Date: Dec-2013
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:32 issue:12 pages:682-99
Article number: 10.1080/15257770.2013.851794
Abstract: 5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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