Title: First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups
Authors: Egle, Brecht
M. Muñoz, Juan
Alonso, Nerea
De Borggraeve, Wim M.
Hoz, Antonio
Díaz-Ortiz, Angel
Alcázar, Jesús # ×
Issue Date: 2014
Publisher: Akademiai Kiado Rt.
Series Title: Journal of Flow Chemistry vol:4 issue:1 pages:22-25
Abstract: The first example of an alkyl–aryl Negishi coupling in a practical, sustainable, and high-yielding process using a silica-supported catalyst in flow is described. Excellent conversions and good functional group compatibility were obtained under very mild conditions. Functionalized alkyl groups were also introduced to provide access to synthetically useful molecules and to demonstrate the versatility of the method. The scalability was assessed, and a throughput of 7.5 mmol/h of processed substrate was achieved. All crude products were free from phosphine derivatives and ready for use in subsequent reaction steps.
ISSN: 2062-249X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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