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Title: Drug-related admissions due to interaction with an old drug, lithium
Authors: De Winter, Sabrina ×
Meersseman, Wouter
Verelst, Sandra
Willems, Ludo
Spriet, Isabel #
Issue Date: Sep-2013
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:68 issue:5 pages:356-358
Abstract: Abstract

Lithium is one of the oldest psychotropic drugs with a well-known narrow therapeutic range and the drugs that interact with lithium elimination are well established. However, patients are still admitted to the emergency department with lithium toxicity due to often overlooked interactions with concomitant drugs. We report on two patients, admitted to the emergency department, with lithium toxicity. One patient presented with aphasia and ataxia, showing moderate toxicity. The other was referred due to coma, illustrating severe lithium toxicity. In both cases, a non-steroidal anti-inflammatory drug was the underlying cause. We highlight the mechanism of this drug-drug interaction and underline the need for thoughtful use of other medications in patients taking lithium. Special attention has to be paid for the non-steroidal antiinflammatory drugs due to the low threshold of prescribing them for the control of acute pain and its availability as free over-the-counter drugs.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Pharmacology and Pharmacotherapy
Laboratory for Clinical Infectious and Inflammatory Disorders
Emergency Medicine
× corresponding author
# (joint) last author

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