Title: The rs1800716 variant in CYP2D6 is associated with an increased double endometrial thickness in postmenopausal women on tamoxifen
Authors: Dieudonne, AS ×
Lambrechts, Diether
Smeets, Dirk
Belmans, Ann
Wildiers, Hans
Paridaens, Robert
Hyonil, C
Timmerman, Dirk
Christiaens, Rose
Vergote, Ignace
Neven, Patrick #
Issue Date: Jan-2014
Publisher: Kluwer Academic Publishers
Series Title: Annals of Oncology vol:25 issue:1 pages:90-5
Article number: 10.1093/annonc/mdt399
Abstract: Tamoxifen remains important in the treatment and prevention of estrogen receptor-positive breast cancer. In postmenopausal women, it can lead to endometrial changes such as cystic appearances, hyperplasia, polyps and endometrial cancer. Tamoxifen is metabolized by cytochrome P450 (CYP450) enzymes to the more active metabolite endoxifen. Several genetic variants in the CYP450 enzymes reduce tamoxifen metabolism, leading to reduced endoxifen levels. We hypothesize that carriers of these variants, which are established poor metabolizers of tamoxifen, do not have the typical tamoxifen-induced increase in endometrial thickness. We test the association between genetic variability in CYP450 enzymes and the increase in double endometrial thickness (DET) as measured through transvaginal ultrasound (TVU).
ISSN: 0923-7534
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
Surgical Oncology
Laboratory of Experimental Oncology
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
Laboratory of Translational Genetics (Vesalius Research Center) (+)
Gynaecological Oncology
ESAT - PSI, Processing Speech and Images
× corresponding author
# (joint) last author

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