Title: IL-2 coordinates IL-2-producing and regulatory T cell interplay
Authors: Amado, Inês F
Berges, Julien
Luther, Rita J
Mailhé, Marie-Pierre
Garcia, Sylvie
Bandeira, Antonio
Weaver, Casey
Liston, Adrian
Freitas, Antonio A # ×
Issue Date: Nov-2013
Publisher: Rockefeller Institute for Medical Research
Series Title: Journal of Experimental Medicine vol:210 issue:12 pages:2707-2720
Article number: 10.1084/jem.20122759
Abstract: Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)-producing CD4(+) T cell (IL-2p) pool using different IL-2 reporter mice. We found that in the absence of either IL-2 or regulatory CD4(+) T (T reg) cells, the number of IL-2p cells increases. Administration of IL-2 decreases the number of cells of the IL-2p cell subset and, pertinently, abrogates their ability to produce IL-2 upon in vivo cognate stimulation, while increasing T reg cell numbers. We propose that control of the IL-2p cell numbers occurs via a quorum sensing-like feedback loop where the produced IL-2 is sensed by both the activated CD4(+) T cell pool and by T reg cells, which reciprocally regulate cells of the IL-2p cell subset. In conclusion, IL-2 acts as a self-regulatory circuit integrating the homeostasis of activated and T reg cells as CD4(+) T cells restrain their growth by monitoring IL-2 levels, thereby preventing uncontrolled responses and autoimmunity.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
× corresponding author
# (joint) last author

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