Title: Detecting rare events using extreme value statistics applied to epileptic convulsions in children
Authors: Luca, Stijn ×
Karsmakers, Peter
Cuppens, Kris
Croonenborghs, Tom
Van de Vel, Anouk
Ceulemans, Berten
Lagae, Lieven
Van Huffel, Sabine
Vanrumste, Bart #
Issue Date: Feb-2014
Publisher: Burgverlag
Series Title: Artificial Intelligence in Medicine vol:60 issue:2 pages:89-96
Abstract: Objective
Nocturnal home monitoring of epileptic children is often not feasible due to the cumbersome manner of seizure detection with the standard method of video electroencephalography monitoring. The goal of this paper is to propose a method for hypermotor seizure detection based on accelerometers that are attached to the extremities.

Supervised methods that are commonly used in literature need annotation of data and hence require expert (neurologist) interaction resulting in a substantial cost. In this paper an unsupervised method is proposed that uses extreme value statistics and seizure detection based on a model of normal behavior that is estimated using all recorded and unlabeled data. In this way the expensive interaction can be avoided.

When applying this method to a labeled dataset, acquired from 7 patients, all hypermotor seizures are detected in 5 of the 7 patients with an average positive predictive value (PPV) of 53%. For evaluating the performance on an unlabeled dataset, seizure events are presented to the system as normal movement events. Since hypermotor seizures are rare compared to normal movements, the very few abnormal events have a negligible effect on the quality of the model. In this way, it was possible to evaluate the system for 3 of the 7 patients when 3% of the training set was composed of seizure events. This resulted in sensitivity scores of 80%, 22% and 90% and a PPV of 89%, 21% and 44% respectively. These scores are comparable with a state-of-the-art supervised machine learning based approach which requires a labeled dataset.

A person-dependent epileptic seizure detection method has been designed that requires little human interaction. In contrast to traditional machine learning approaches, the imbalance of the dataset does not cause substantial difficulties.
ISSN: 0933-3657
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Groep Gezondheid en Welzijn TM K - miscellaneous
Electrical Engineering (ESAT) TC, Technology Campus Geel
Technologiecluster ESAT Elektrotechnische Engineering
Computer Science Technology TC, Technology Campus Geel
Technologiecluster Computerwetenschappen
Organ Systems (+)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Electrical Engineering (ESAT) TC, Technology Campus Diepenbeek
× corresponding author
# (joint) last author

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