Title: Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain
Authors: Van Laere, Koen ×
Ahmad, Rawaha
Hudyana, Hendra
Dubois, Kristof
Schmidt, Mark E
Celen, Sofie
Bormans, Guy
Koole, Michel #
Issue Date: Aug-2013
Publisher: Society of Nuclear Medicine
Series Title: Journal of Nuclear Medicine vol:54 issue:8 pages:1285-93
Article number: 10.2967/jnumed.112.118679
Abstract: Phosphodiesterase 10A (PDE10A) plays a central role in striatal signaling and is implicated in several neuropsychiatric disorders, such as movement disorders and schizophrenia. We performed initial brain kinetic modeling of the novel PDE10A tracer (18)F-JNJ-42259152 (2-[[4-[1-(2-(18)F-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-3,5-dimethyl-pyridine) and studied test-retest reproducibility in healthy volunteers.
ISSN: 0161-5505
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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