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Title: 11C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists
Authors: Van Laere, Koen ×
Sanabria-Bohórquez, Sandra M
Mozley, David P
Burns, Donald H
Hamill, Terence G
Van Hecken, Anne
De Lepeleire, Inge
Koole, Michel
Bormans, Guy
de Hoon, Jan
Depré, Marleen
Cerchio, Kristine
Plalcza, John
Han, Lingling
Renger, John
Hargreaves, Richard J
Iannone, Robert #
Issue Date: Jan-2014
Publisher: Society of Nuclear Medicine
Series Title: Journal of Nuclear Medicine vol:55 issue:1 pages:65-72
Abstract: The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis and release of histamine and modulates the release of other major neurotransmitters. H3 receptor inverse agonists (IAs) may be efficacious in the treatment of various central nervous system disorders, including excessive daytime sleepiness, attention deficit hyperactivity disorder, Alzheimer disease, ethanol addiction, and obesity.
URI: 
ISSN: 0161-5505
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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