Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort
Bartha, István × Assel, Matthias Sloot, Peter Ma Zazzi, Maurizio Torti, Carlo Schülter, Eugen De Luca, Andrea Sönnerborg, Anders Abecasis, Ana B Van Laethem, Kristel Rosi, Andrea Svärd, Jenny Paredes, Roger van de Vijver, David Amc Vandamme, Anne-Mieke Müller, Viktor #
BMC Infectious Diseases vol:13 pages:537
Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.