Title: Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study
Authors: Kamide, Kei
Asayama, Kei
Katsuya, Tomohiro
Ohkubo, Takayoshi
Hirose, Takuo
Inoue, Ryusuke
Metoki, Hirohito
Kikuya, Masahiro
Obara, Taku
Hanada, Hironori
Thijs, Lutgarde
Kuznetsova, Tatiana
Noguchi, Yuichi
Sugimoto, Ken
Ohishi, Mitsuru
Morimoto, Shigeto
Nakahashi, Takeshi
Takiuchi, Shin
Ishimitsu, Toshihiko
Tsuchihashi, Takuya
Soma, Masayoshi
Higaki, Jitsuo
Matsuura, Hideo
Shinagawa, Tatsuo
Sasaguri, Toshiyuki
Miki, Tetsuro
Takeda, Kazuo
Shimamoto, Kazuaki
Ueno, Michio
Hosomi, Naohisa
Kato, Jyouji
Komai, Norio
Kojima, Shunichi
Sase, Kazuhiro
Miyata, Toshiyuki
Tomoike, Hitonobu
Kawano, Yuhei
Ogihara, Toshio
Rakugi, Hiromi
Staessen, Jan A
Imai, Yutaka # ×
Issue Date: Nov-2013
Publisher: Ashley Publications
Series Title: Pharmacogenomics vol:14 issue:14 pages:1709-21
Article number: 10.2217/pgs.13.161
Abstract: Background: Patients with mild-to-moderate essential hypertension in the HOMED-BP trial were randomly allocated to first-line treatment with a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB). Methods: We recruited 265 (93 for CCB, 71 for ACEI and 101 for ARB) patients who completed the genomic study. Home blood pressure was measured for 5 days off-treatment before randomization and for 5 days after 2-4 weeks of randomized drug treatment. Genotyping was performed by 500K DNA microarray chips. The blood pressure responses to the three drugs were analyzed separately as a quantitative trait. For replication of SNPs with p < 10(-4), we used the multicenter GEANE study, in which patients were randomized to valsartan or amlodipine. Results: SNPs in PICALM, TANC2, NUMA1 and APCDD1 were found to be associated with CCB responses and those in ABCC9 and YIPF1 were found to be associated with ARB response with replication. Conclusion: Our approach, the first based on high-fidelity phenotyping by home blood pressure measurement, might be a step in moving towards the personalized treatment of hypertension. Original submitted 29 April 2013; Revision submitted 14 August 2013.
ISSN: 1462-2416
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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