Title: Increased proximal reflux in a hypersensitive esophagus might explain symptoms resistant to proton pump inhibitors in patients with gastroesophageal reflux disease
Authors: Rohof, Wout O
Bennink, Roelof J
de Jonge, Hugo
Boeckxstaens, Guy # ×
Issue Date: Oct-2014
Publisher: W.B. Saunders for the American Gastroenterological Association
Series Title: Clinical Gastroenterology and Hepatology vol:12 issue:10 pages:1647-55
Article number: S1542-3565(13)01680-7
Abstract: Approximately 30% of patients with gastroesophageal reflux disease (GERD) have symptoms resistant to treatment with proton pump inhibitors (PPIs). Several mechanisms such as esophageal hypersensitivity, increased mucosal permeability and possibly the position of the gastric acid pocket might underlie a partial response to PPI. To what extent these mechanisms interact and contribute to PPI resistant symptoms has however not been investigated previously.
ISSN: 1542-3565
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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