Author:

Keywords:

Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ALVEOLAR MACROPHAGES, INTRACELLULAR CA2+, STIMULATION, SURVIVAL, NEURONS, Adenosine Triphosphate, Aniline Compounds, Animals, Calcium, Enteric Nervous System, Ganglionic Stimulants, Gastric Mucosa, Immunohistochemistry, Macrophage Activation, Macrophages, Male, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Myenteric Plexus, Neurons, Nicotine, Receptors, Nicotinic, Stomach, Xanthenes, General Science & Technology

Abstract:

The cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR). This concept has however not been demonstrated at a cellular level in intact tissue. To this end, we have studied the effect of nicotine on the activation of resident macrophages in a mouse stomach preparation by means of calcium imaging.