Title: In vivo type 1 cannabinoid receptor availability in Alzheimer's disease
Authors: Ahmad, Rawaha ×
Goffin, Karolien
Van den Stock, Jan
De Winter, Fran├žois-Laurent
Cleeren, Evy
Bormans, Guy
Tournoy, Jos
Persoons, Philippe
Van Laere, Koen
Vandenbulcke, Mathieu #
Issue Date: Feb-2014
Publisher: Elsevier
Series Title: European Neuropsychopharmacology vol:24 issue:2 pages:242-50
Article number: S0924-977X(13)00294-0
Abstract: The endocannabinoid system (ECS) is an important modulatory and potentially neuroprotective homeostatic system in the brain. In Alzheimer's disease (AD), the role of type 1 cannabinoid receptor (CB1R) is unclear, with contradictory findings in post-mortem studies showing upregulation, downregulation or unchanged CB1R status. We have investigated CB1R availability in vivo in patients with AD, in relation to amyloid deposition, cognitive functioning and apolipoprotein E (ApoE) genotype. Eleven AD patients and 7 healthy volunteers (HV) underwent combined [(18)F]MK-9470 PET and [(11)C]PIB PET scans to assess CB1R availability and amyloid deposition, respectively, and T1 volumetric MRI for partial volume correction. We found no difference in CB1R availability between AD and HV, VOI-based fractional uptake values (FUR) were 0.043±0.01 for AD and 0.045±0.01 for controls (p=0.9). CB1R availability did not correlate with neuropsychological test scores and was not modulated by ApoE genotype. As expected, global [(11)C]PIB SUVR (standardized uptake value ratio) was increased in AD (SUVR 1.9±0.3) compared to HV (1.2±0.1) with p<0.001, but no correlation was found between amyloid β (Aβ) deposition and CB1R availability. In conclusion, we found no in vivo evidence for a difference in CB1R availability in AD compared to age-matched controls. Taken together with recently reported in vivo CB1R changes in Parkinson's and Huntington's disease, these data suggest that the CB1R is differentially involved in neurodegenerative disorders.
ISSN: 0924-977X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gerontology and Geriatrics
Radiopharmaceutical Research
Laboratory for Neuro- and Psychofysiology
Research Group Psychiatry
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2014, Eur Neuropsycho, Ahmad, In vivo type 1 cannabinoid receptor.pdf Published 1040KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science